Renal function and physical fitness after 12-mo supervised training in kidney transplant recipients

To evaluate the effect of a 12-mo supervised aerobic and resistance training, on renal function and exercise capacity compared to usual care recommendations

PluS Nanoparticles as a tool to control the metal complex stoichiometry of a new thio-aza macrocyclic chemosensor for Ag(I) and Hg(II) in water

We report here the synthesis of a new thio-​aza macrocyclic chemosensor based on the 2,​5-​diphenyl[1,​3,​4]​oxadiazole in which two thioether groups were inserted in a macrocycle with the aim to make it suitable for the coordination of soft and heavy metal ions. In acetonitrile soln., the fluorescence of the chemosensor changes upon addn. of different metal ions, such as Cu(II)​, Zn(II)​, Cd(II)​, Pb(II)​, Hg(II) and Ag(I)​, that form a not fluorescent ML species and a fluorescent M2L species characterized also via NMR expts. The hosting of the chemosensor inside the PluS Nanoparticles leads to a high water soly., allowing to perform the metal detection without the use of addnl. solvents and also induced an higher selectivity towards Ag(I) and Hg(II)​. Moreover, it was demonstrated for the first time the possibility to control the stoichiometry of the formed complex upon changing the no. of ligands per nanoparticles. To our opinion, this possibility can give an addnl. tool for the tuning of the affinity and selectivity of the chemosensor that could be of great interest for the design of more and more efficient systems

Cancer-Cell-Targeted Theranostic Cubosomes

none12siThis work was devoted to the development of a new type of lipid-based (cubosome) theranostic nanoparticle able to simultaneously host camptothecin, a potent anticancer drug, and a squarain-based NIR-emitting fluorescent probe. Furthermore, to confer targeting abilities on these nanoparticles, they were dispersed using mixtures of Pluronic F108 and folate-conjugated Pluronic F108 in appropriate ratios. The physicochemical characterization, performed via SAXS, DLS, and cryo-TEM techniques, proved that aqueous dispersions of such cubosomes can be effectively prepared, while the photophysical characterization demonstrated that these nanoparticles may be used for in vivo imaging purposes. The superior ability of these innovative nanoparticles in targeting cancer cells was emphasized by investigating the lipid droplet alterations induced in HeLa cells upon exposure to targeted and nontargeted cubosomes.mixedClaudia Caltagirone;Angela Maria Falchi;Sandrina Lampis;Vito Lippolis;Valeria Meli;Maura Monduzzi;Luca Prodi;Judith Schmidt;Massimo Sgarzi;Yeshayahu Talmon;Ranieri Bizzarri;Sergio MurgiaClaudia Caltagirone;Angela Maria Falchi;Sandrina Lampis;Vito Lippolis;Valeria Meli;Maura Monduzzi;Luca Prodi;Judith Schmidt;Massimo Sgarzi;Yeshayahu Talmon;Ranieri Bizzarri;Sergio Murgi